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Childhood leukemia survivors exhibit deficiencies in sensory and cognitive processes, as reflected by event-related brain potentials after completion of curative chemotherapy: A preliminary investigation

Published on Sep 14, 2019in Journal of Clinical and Experimental Neuropsychology1.994
· DOI :10.1080/13803395.2019.1623865
Kelin M. Brace (Albert Einstein College of Medicine), Wei Wei Lee3
Estimated H-index: 3
(Albert Einstein College of Medicine)
+ 1 AuthorsElyse S. Sussman36
Estimated H-index: 36
(Albert Einstein College of Medicine)
Abstract
ABSTRACTObjective: The purpose of this study was to characterize post-chemotherapy sensory, memory, and attention abilities in childhood survivors of acute lymphoblastic leukemia (ALL) to better un...
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References68
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#1Simone J. Hearps (University of Melbourne)H-Index: 6
#2Marc L. Seal (University of Melbourne)H-Index: 36
Last. Cinzia R. De Luca (Royal Children's Hospital)H-Index: 11
view all 7 authors...
Cognitive late-effects have been identified in patients treated with chemotherapy-only protocols for childhood acute lymphoblastic leukemia (ALL), yet the underlying neuropathology is not well understood. This review synthesized recent findings from eight articles investigating the relationship between neurocognitive and neuroimaging outcomes for patients treated for ALL with chemotherapy-only protocols. Reported cognitive domains, imaging methods, and neuroanatomy examined were variable. Despit...
12 CitationsSource
#1Cory Pierson (Wheaton College (Illinois))H-Index: 1
#2Erin Waite (Wheaton College (Illinois))H-Index: 1
Last. Ben Pyykkonen (Wheaton College (Illinois))H-Index: 1
view all 3 authors...
Background Long-term neuropsychological deficits associated with pediatric cancers and the related treatments have been consistently reported. Whole brain cranial radiation therapy (CRT) is associated with neurocognitive impairment. As a result, physicians are reticent to use CRT in favor of systemic or intrathecal chemotherapy, which have a less clear impact on cognition. Procedure The current meta-analysis examined post-treatment neuropsychological performance of children diagnosed with cancer...
11 CitationsSource
#1AnnaLynn M. Williams (UR: University of Rochester)H-Index: 4
#2Clive S. Zent (URMC: University of Rochester Medical Center)H-Index: 41
Last. Michelle C. Janelsins (URMC: University of Rochester Medical Center)H-Index: 31
view all 3 authors...
Summary Cancer-related cognitive impairment (CRCI) is an important clinical problem for cancer patients and survivors. In this review, we summarize studies investigating the occurrence of impaired cognition in patients with haematological malignancies. Most published studies focus on survivors of childhood acute lymphoblastic leukaemia and primary central nervous system lymphoma. We also discuss studies conducted in acute myeloid leukaemia, myelodysplastic syndromes, chronic myeloid leukaemia, H...
16 CitationsSource
#1Eric C. Larsen (Maine Medical Center)H-Index: 5
#2Meenakshi Devidas (UF: University of Florida)H-Index: 63
Last. William L. Carroll (NYU: New York University)H-Index: 59
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PurposeSurvival for children and young adults with high-risk B-acute lymphoblastic leukemia has improved significantly, but 20% to 25% of patients are not cured. Children’s Oncology Group study AALL0232 tested two interventions to improve survival.Patients and MethodsBetween January 2004 and January 2011, AALL0232 enrolled 3,154 participants 1 to 30 years old with newly diagnosed high-risk B-acute lymphoblastic leukemia. By using a 2 × 2 factorial design, 2,914 participants were randomly assigne...
91 CitationsSource
#1Lisa M. Jacola (St. Jude Children's Research Hospital)H-Index: 6
#2Kevin R. Krull (St. Jude Children's Research Hospital)H-Index: 41
Last. Heather M. Conklin (St. Jude Children's Research Hospital)H-Index: 27
view all 7 authors...
PurposeSurvivors of childhood acute lymphoblastic leukemia (ALL) treated with CNS-directed chemotherapy are at risk for neurocognitive deficits. Prospective longitudinal studies are needed to clarify the neurodevelopmental trajectory in this vulnerable population.MethodsPatients enrolled in the St. Jude Total Therapy Study XV, which omitted prophylactic cranial radiation therapy in all patients, completed comprehensive neuropsychological assessments at induction (n = 142), end of maintenance (n ...
39 CitationsSource
#1Adriani Kanellopoulos (University of Oslo)H-Index: 10
#2Stein Andersson (University of Oslo)H-Index: 21
Last. Ellen Ruud (Oslo University Hospital)H-Index: 18
view all 9 authors...
Background There is a concern regarding long-term cognitive late effects after treatment for acute lymphoblastic leukemia (ALL). The present study assessed neuropsychological function in very long-term childhood ALL survivors treated with chemotherapy only. We also investigated associations between neurocognitive performance and individual treatment load. Procedure One-hundred and twelve adult ALL survivors, diagnosed 1970–2002 before age 16 and treated with chemotherapy only, and 100 comparison...
32 CitationsSource
#1Andrew E. Place (Harvard University)H-Index: 15
#2Kristen E. Stevenson (Harvard University)H-Index: 37
Last. Lewis B. Silverman (Harvard University)H-Index: 64
view all 23 authors...
Summary Background l-asparaginase is a universal component of treatment for childhood acute lymphoblastic leukaemia, and is usually administered intramuscularly. Pegylated Escherichia coli asparaginase (PEG-asparaginase) has a longer half-life and is potentially less immunogenic than the native Escherichia coli ( E coli ) preparation, and can be more feasibly administered intravenously. The aim of the Dana-Farber Cancer Institute Acute Lymphoblastic Leukaemia Consortium Protocol 05-001 (DFCI 05-...
59 CitationsSource
#1Jennifer Lynn Krizman (NU: Northwestern University)H-Index: 13
#2Adam Tierney (NU: Northwestern University)H-Index: 16
Last. Nina KrausH-Index: 83
view all 6 authors...
Abstract Objective Considerable attention has been devoted to understanding development of the auditory system during the first few years of life, yet comparatively little is known about maturation during adolescence. Moreover, the few studies investigating auditory system maturation in late childhood have employed a cross-sectional approach. Methods To better understand auditory development in adolescence, we used a longitudinal design to measure the subcortical encoding of speech syllables in ...
16 CitationsSource
The most common cancer in childhood is now curable in 90% of patients. Current efforts are focused on devising molecular-based therapy for the subsets of acute lymphoblastic leukemia that are most resistant to current therapy.
338 CitationsSource
#1Neel S. Iyer (Lake Erie College of Osteopathic Medicine)H-Index: 2
#2Lyn Balsamo (Yale University)H-Index: 15
Last. Nina S. Kadan-Lottick (Yale University)H-Index: 25
view all 4 authors...
Therapy for childhood acute lymphoblastic leukemia (ALL) is associated with 5-year survival rates of ∼90% even after largely eliminating cranial radiation. This meta-analysis assesses the long-term neurocognitive functioning after chemotherapy-only regimens among survivors of childhood ALL. We conducted a systematic review to identify studies that evaluated long-term neurocognitive functioning following treatment of ALL by searching MEDLINE/PubMed, Database of Abstracts of Reviews of Effects, an...
72 CitationsSource
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