Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing.The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an...