Review paper
The Lysosome Signaling Platform: Adapting With the Times
Abstract
Lysosomes are the terminal degradative compartment of autophagy, endocytosis and phagocytosis. What once was viewed as a simple acidic organelle in charge of macromolecular digestion has emerged as a dynamic organelle capable of integrating cellular signals and producing signal outputs. In this review, we focus on the concept that the lysosome surface serves as a platform to assemble major signaling hubs like mTORC1, AMPK, GSK3 and the...
Paper Details
Title
The Lysosome Signaling Platform: Adapting With the Times
Published Date
Jun 20, 2019
Volume
7
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