Original paper
Acquired resistance during adoptive cell therapy by transcriptional silencing of immunogenic antigens
Abstract
Immunotherapies such as adoptive cell therapy (ACT) are promising treatments for solid cancers. However, relapsing disease remains a problem and the molecular mechanisms underlying resistance are poorly defined. We postulated that the deregulated epigenetic landscape in cancer cells could underpin the acquisition of resistance to immunotherapy. To address this question, two preclinical models of ACT were employed to study transcriptional and...
Paper Details
Title
Acquired resistance during adoptive cell therapy by transcriptional silencing of immunogenic antigens
Published Date
Jun 3, 2019
Journal
Volume
8
Issue
8
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Notes
History