Quantitative analysis of ATM phosphorylation in lymphocytes
Abstract
Since many anticancer therapies target DNA and DNA damage response pathways, biomarkers of DNA damage endpoints may prove valuable in basic and clinical cancer research. Ataxia telangiectasia-mutated (ATM) kinase is the principal regulator of cellular responses to DNA double-strand breaks (DSBs). In humans, ATM autophosphorylation at serine 1981 (p-S1981) is an immediate molecular response to nascent DSBs and ionizing radiation (IR). Here we...
Paper Details
Title
Quantitative analysis of ATM phosphorylation in lymphocytes
Published Date
Aug 1, 2019
Journal
Volume
80
Pages
1 - 7
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