MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance

•HBV infection results in altered mCD100 expression and serum sCD100 levels. •sCD100 can increase anti-HBV CTL response and accelerate HBV clearance. •mCD100 shedding and sCD100 formation is mediated by MMP2 and MMP9. •CHB patients show decreased serum MMP2 and sCD100 levels. •MMP2/9 inhibition suppresses anti-HBV CTL response and delays HBV clearance. Background & Aims CD100 is constitutively expressed on T cells and can be cleaved from the...