1347-P: Improvement in Peripheral Insulin Sensitivity (IS) with Metformin (MET) in Adolescents with Type 1 Diabetes (T1D) Is Not Mediated by Muscle Mitochondrial Change

T1D youth are insulin resistant and we recently demonstrated that whole-body IS improved after 3 months of MET therapy. We also found that youth with T1D and type 2 diabetes both have skeletal muscle mitochondrial dysfunction that correlated with IS, but with a unique pattern in T1D. We aimed to determine if improvement in IS in T1D youth following MET was related to improvement in mitochondrial function. Forty-nine youth aged 12-21 years with...