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Type 2 diabetes in midlife and risk of cerebrovascular disease in late life: a prospective nested case−control study in a nationwide Swedish twin cohort

Published on Jun 5, 2019in Diabetologia7.11
· DOI :10.1007/s00125-019-4892-3
Rongrong Yang1
Estimated H-index: 1
(Tianjin Medical University),
Nancy L. Pedersen102
Estimated H-index: 102
(SC: University of Southern California)
+ 5 AuthorsWeili Xu19
Estimated H-index: 19
(Tianjin Medical University)
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Abstract
Aims/hypothesis We aimed to examine the association between midlife type 2 diabetes mellitus and cerebrovascular disease (CBD) in late life, and further to explore whether genetic and early-life familial environmental factors (such as shared childhood socioeconomic status and adolescent environment) play a role in this association.
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References43
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Published on May 1, 2019in International Journal of Cancer4.98
Cuiping Bao4
Estimated H-index: 4
(Tianjin Medical University),
Rongrong Yang1
Estimated H-index: 1
(Tianjin Medical University)
+ 5 AuthorsWeili Xu3
Estimated H-index: 3
(Tianjin Medical University)
Published on Aug 15, 2018in International Journal of Cancer4.98
Cuiping Bao4
Estimated H-index: 4
,
Nancy L. Pedersen102
Estimated H-index: 102
+ 5 AuthorsWeili Xu19
Estimated H-index: 19
Published on Aug 1, 2017in Neurology8.69
Susanna C. Larsson61
Estimated H-index: 61
(University of Cambridge),
Rob Scott78
Estimated H-index: 78
+ 7 AuthorsHugh S. Markus91
Estimated H-index: 91
Objective: To implement a mendelian randomization (MR) approach to determine whether type 2 diabetes mellitus (T2D), fasting glucose, fasting insulin, and body mass index (BMI) are causally associated with specific ischemic stroke subtypes. Methods: MR estimates of the association between each possible risk factor and ischemic stroke subtypes were calculated with inverse-variance weighted (conventional) and weighted median approaches, and MR-Egger regression was used to explore pleiotropy. The n...
Published on Dec 1, 2016in Cardiovascular Diabetology5.95
François R. Jornayvaz23
Estimated H-index: 23
(UNIL: University of Lausanne),
Peter Vollenweider21
Estimated H-index: 21
(UNIL: University of Lausanne)
+ 3 AuthorsPedro Marques-Vidal29
Estimated H-index: 29
(UNIL: University of Lausanne)
Background Low birth weight is associated with increased rates of obesity, insulin resistance and type 2 diabetes, but the precise mechanisms for this association remain unclear. We aimed to assess the relationships between birth weight and markers of glucose homeostasis or obesity in adults.
Published on Apr 1, 2016in The American Journal of the Medical Sciences1.96
Rong Chen1
Estimated H-index: 1
(MUSC: Medical University of South Carolina),
Bruce Ovbiagele41
Estimated H-index: 41
(MUSC: Medical University of South Carolina),
Wuwei Feng15
Estimated H-index: 15
(MUSC: Medical University of South Carolina)
There has been a significant increase in obesity rates worldwide with the corresponding surge in diabetes. Diabetes causes various microvascular and macrovascular changes often culminating in major clinical complications, 1 of which, is stroke. Although gains have been made over the last 2 decades in reducing the burden of stroke, the recent rise in rates of diabetes threatens to reverse these advances. Of the several mechanistic stroke subtypes, individuals with diabetes are especially suscepti...
Published on Feb 1, 2015in The Lancet Diabetes & Endocrinology24.54
Anoop Dinesh Shah19
Estimated H-index: 19
(UCL: University College London),
Claudia Langenberg81
Estimated H-index: 81
(University of Cambridge)
+ 7 AuthorsHarry Hemingway56
Estimated H-index: 56
(UCL: University College London)
Summary Background The contemporary associations of type 2 diabetes with a wide range of incident cardiovascular diseases have not been compared. We aimed to study associations between type 2 diabetes and 12 initial manifestations of cardiovascular disease. Methods We used linked primary care, hospital admission, disease registry, and death certificate records from the CALIBER programme, which links data for people in England recorded in four electronic health data sources. We included people wh...
Published on Jun 1, 2014in The Lancet59.10
Linong Ji1
Estimated H-index: 1
(PKU: Peking University)
Published on Jun 1, 2014in The Lancet59.10
Sanne A.E. Peters26
Estimated H-index: 26
(University of Cambridge),
Rachel R. Huxley59
Estimated H-index: 59
(UQ: University of Queensland),
Mark Woodward110
Estimated H-index: 110
(Johns Hopkins University)
Summary Background Diabetes mellitus is a major cause of death and disability worldwide and is a strong risk factor for stroke. Whether and to what extent the excess risk of stroke conferred by diabetes differs between the sexes is unknown. We did a systematic review and meta-analysis to estimate the relative effect of diabetes on stroke risk in women compared with men. Methods We systematically searched PubMed for reports of prospective, population-based cohort studies published between Jan 1, ...
Published on Jun 1, 2013in Stroke6.05
Jane Khoury65
Estimated H-index: 65
,
Dawn Kleindorfer52
Estimated H-index: 52
+ 8 AuthorsJoseph P. Broderick109
Estimated H-index: 109
Background and Purpose— We previously reported increased incidence of ischemic stroke among both blacks and whites with diabetes mellitus, especially in those aged Methods— This is a population-based study. First ischemic strokes among black and white residents of the 5-county Greater Cincinnati/Northern Kentucky region, aged ≥20 years, for periods 7/1993 to 6/1994, 1999, and 2005, were included in this analysis. Incidence rates were adjusted for sex, race, and age, as appropriate, to the 2000 U...
Published on Jun 7, 2012in BMJ27.60
Meng Lee18
Estimated H-index: 18
,
Jeffrey L. Saver99
Estimated H-index: 99
+ 3 AuthorsBruce Ovbiagele41
Estimated H-index: 41
Objectives To assess the association between pre-diabetes and risk of stroke, and to evaluate whether this relation varies by diagnostic criteria for pre-diabetes. Design Systematic review and meta-analysis of prospective studies. Data sources A search of Medline, Embase, and the Cochrane Library (1947 to 16 July 2011) was supplemented by manual searches of bibliographies of key retrieved articles and relevant reviews. Selection criteria Prospective cohort studies that reported multivariate adju...
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