1834-P: Pancreatic Fat Associates with Impaired Insulin Secretion in Genetically Predisposed Individuals

Background: Pancreatic fat (PF) related beta-cell failure might play a role in the pathophysiology of type 2 diabetes (T2D). We hypothesized that the effect of PF on beta-cell function can be modeled as a gene x environment interaction. To this end, we investigated the association of PF with insulin secretion in subjects with different genetic predisposition for T2D. Methods: A genome-wide polygenic risk score (gwPRS) was computed combining...