2120-P: Knockdown of ETV5 Enhances Nitric Oxide (NO) Production and Caspase-Independent Cell Death in Pancreatic Beta Cells

ETV5 (E-twenty six variant gene 5) belongs to the E-twenty six transcription factor family that regulates various biological processes including proliferation, differentiation and apoptosis. Genome-wide association studies linked ETV5 with human obesity. ETV5 is expressed in insulin producing pancreatic beta cells and its deletion in Etv5-/- mice results in less weight gain during high fat diet and impaired glucose tolerance due to reduced...