Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility
Abstract
Modern genetic studies indicate that human brain evolution is driven primarily by changes in gene regulation, which requires understanding the biological function of largely non-coding gene regulatory elements, many of which act in tissue specific manner. We leverage chromatin interaction profiles in human fetal and adult cortex to assign three classes of human-evolved elements to putative target genes. We find that human-evolved elements...
Paper Details
Title
Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility
Published Date
Jun 3, 2019
Journal
Volume
10
Issue
1
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