128-OR: Clustering of Metabolomics, Clinical Biomarkers, and Ectopic Liver Fat in Children/Adolescents: An Integrated Network Analysis

Hepatic fat accumulation is often associated with cardiometabolic disease (CMD) risk factors in children, but the mechanism is unclear. We measured untargeted metabolomics in plasma from 219 obese children/adolescents with (37%) and without (63%) fatty liver assessed by magnetic resonance imaging. An integrative network analysis, which involved several steps including pairwise association analyses and a multilevel community detection algorithm,...