Genome-wide cell-free DNA fragmentation in patients with cancer

Nature64.80
Volume: 570, Issue: 7761, Pages: 385 - 389
Published: Jun 20, 2019
Abstract
Cell-free DNA in the blood provides a non-invasive diagnostic avenue for patients with cancer1. However, characteristics of the origins and molecular features of cell-free DNA are poorly understood. Here we developed an approach to evaluate fragmentation patterns of cell-free DNA across the genome, and found that profiles of healthy individuals reflected nucleosomal patterns of white blood cells, whereas patients with cancer had altered...
Paper Details
Title
Genome-wide cell-free DNA fragmentation in patients with cancer
Published Date
Jun 20, 2019
Journal
Volume
570
Issue
7761
Pages
385 - 389
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