Insulin sensitivity improvement with exercise training is mediated by body weight loss in subjects with metabolic syndrome

To determine whether exercise training improves insulin actions through concomitant body weight loss (BWL). Subjects (aged 55 ± 8 years) with metabolic syndrome (MetS), prediabetes (fasting blood glucose: 111 ± 2 mg·dL−1, HbA1c: 5.85 ± 0.05%) and abdominal obesity (waist circumference: 104 ± 7.9 cm) were randomly allocated to either a group performing aerobic interval training (EXER; n = 76) or a sedentary group receiving lifestyle counselling...