The dorsal skinfold chamber: A valuable model for the in vivo evaluation of topical formulations

In this study, we introduce the mouse dorsal skinfold chamber model as a valuable approach for the in vivo evaluation of topical formulations. For this purpose, dorsal skinfold chambers were implanted into BALB/c mice. Tumor necrosis factor (TNF)‐α was administered to the chamber tissue for the local induction of inflammation followed by the application of diclofenac‐containing or diclofenac‐free (control) gel onto the skin of the chamber...