Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes
Abstract
Type 2 diabetes (T2D) is an age-related disease. Although changes in function and proliferation of aged β cells resemble those preceding the development of diabetes, the contribution of β cell aging and senescence remains unclear. We generated a β cell senescence signature and found that insulin resistance accelerates β cell senescence leading to loss of function and cellular identity and worsening metabolic profile. Senolysis (removal of...
Paper Details
Title
Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes
Published Date
Jul 1, 2019
Journal
Volume
30
Issue
1
Pages
129 - 142.e4
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Notes
History