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Success of Direct-Acting, Antiviral-Based Therapy for Chronic Hepatitis C is Not Affected by Type 2 Diabetes

Published on May 31, 2019in Clinical Diabetes
路 DOI :10.2337/cd18-0112
Blake A. Niccum3
Estimated H-index: 3
(Harvard University),
Jonathan G. Stine2
Estimated H-index: 2
(Penn State Milton S. Hershey Medical Center)
+ 3 AuthorsNeeral L. Shah17
Estimated H-index: 17
(University of Virginia Health System)
Abstract
IN BRIEF Chronic hepatitis C virus (HCV) is a risk factor for type 2 diabetes. In the era of interferon-based HCV therapy, type 2 diabetes was associated with decreased likelihood of sustained virologic response (SVR). Preliminary studies suggest that type 2 diabetes may not reduce the efficacy of regimens involving direct-acting antiviral (DAA) medications. We aimed to determine whether preexisting type 2 diabetes is associated with a reduced rate of SVR achieved 12 weeks after treatment of HCV with DAA-based regimens.
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