Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases

Inflammatory bowel diseases (IBD) are a group of complex and multifactorial disorders with unknown etiology. Chronic intestinal inflammation develops against resident intestinal bacteria in genetically susceptible hosts. We hypothesized that host intestinal immunoglobulin (Ig) G can be used to identify bacteria involved in IBD pathogenesis.IgG-bound and -unbound microorganisms were collected from 32 pediatric terminal ileum aspirate washes...