When does the youthfulness of the female brain emerge?

Goyal et al. (1) report in PNAS that the female adult brain has a persistently lower metabolic brain age compared with the male brain at the same chronological age. In interpreting this remarkable finding, the authors propose that sex-related differences in brain development may, in part, play a role in “setting” the female brain at a younger initial brain age at puberty, allowing them to maintain a younger brain throughout adulthood. We argue...