Inferring cancer dependencies on metabolic genes from large-scale genetic screens
Abstract
Cancer cells reprogram their metabolism to survive and propagate. Thus, targeting metabolic rewiring in tumors is a promising therapeutic strategy. Genome-wide RNAi and CRISPR screens are powerful tools for identifying genes essential for cancer cell proliferation and survival. Integrating loss-of-function genetic screens with genomics and transcriptomics datasets reveals molecular mechanisms that underlie cancer cell dependence on specific...
Paper Details
Title
Inferring cancer dependencies on metabolic genes from large-scale genetic screens
Published Date
Apr 30, 2019
Journal
Volume
17
Issue
1
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