Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy
Abstract
FAM134B/RETREG1 is a selective ER-phagy receptor that regulates the size and shape of the endoplasmic reticulum. The structure of its reticulon-homology domain (RHD), an element shared with other ER-shaping proteins, and the mechanism of membrane shaping remain poorly understood. Using molecular modeling and molecular dynamics (MD) simulations, we assemble a structural model for the RHD of FAM134B. Through MD simulations of FAM134B in flat and...
Paper Details
Title
Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy
Published Date
May 30, 2019
Journal
Volume
10
Issue
1
Pages
2370
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