A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing
Abstract
The HIV-1 capsid, which is made from individual viral capsid proteins (CA), is a target for a number of antiviral compounds, including the small-molecule inhibitor PF74. In the present study, we utilized PF74 to identify a transmitted/founder (T/F) strain that shows increased capsid stability. Interestingly, PF74-resistant variants prevented cGAS-dependent innate immune activation under a condition where the other T/F strains induced type I...
Paper Details
Title
A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing
Published Date
Aug 15, 2019
Journal
Volume
93
Issue
16
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