Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification

Importance

Genetic variants at theLPAlocus are associated with both calcific aortic valve stenosis (CAVS) and coronary artery disease (CAD). Whether these variants are associated with CAVS in patients with CAD vs those without CAD is unknown.

Objective

To study the associations ofLPAvariants with CAVS in a cohort of patients undergoing heart surgery andLPAwith CAVS in patients with CAD vs those without CAD...