Regulated, sequential processing by multiple proteases is required for proper maturation and release ofBordetellafilamentous hemagglutinin

Volume: 112, Issue: 3, Pages: 820 - 836
Published: Jun 19, 2019
Abstract
Filamentous hemagglutinin (FHA) is a critically important virulence factor produced by Bordetella species that cause respiratory infections in humans and other animals. It is also a prototypical member of the widespread two partner secretion (TPS) pathway family of proteins. First synthesized as a ~370 kDa protein called FhaB, its C-terminal ~1,200 amino acid 'prodomain' is removed during translocation to the cell surface via the outer membrane...
Paper Details
Title
Regulated, sequential processing by multiple proteases is required for proper maturation and release ofBordetellafilamentous hemagglutinin
Published Date
Jun 19, 2019
Volume
112
Issue
3
Pages
820 - 836
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