Causes and effects of haploinsufficiency
Abstract
Haploinsufficiency is a form of genetic dominance and is the underlying mechanism of numerous human inherited conditions in which the causal genes are sensitive to altered dosage. This review examines the poorly understood relationships between haploinsufficiency, dosage sensitivity and genetic dominance, whose common theme is the existence of nonlinear relationships between genotype and phenotype. We present an up‐to‐date account of the bases...
Paper Details
Title
Causes and effects of haploinsufficiency
Published Date
May 31, 2019
Journal
Volume
94
Issue
5
Pages
1774 - 1785
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Notes
History