Restored immune cell functions upon clearance of senescence in the irradiated splenic environment
Abstract
Some studies show eliminating senescent cells rejuvenate aged mice and attenuate deleterious effects of chemotherapy. Nevertheless, it remains unclear whether senescence affects immune cell function. We provide evidence that exposure of mice to ionizing radiation (IR) promotes the senescent‐associated secretory phenotype (SASP) and expression of p16 INK4a in splenic cell populations. We observe splenic T cells exhibit a reduced proliferative...
Paper Details
Title
Restored immune cell functions upon clearance of senescence in the irradiated splenic environment
Published Date
May 31, 2019
Journal
Volume
18
Issue
4
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