Action of cocaine involves depletion of dopaminergic and serotonergic storage vesicles

Pages: 651505
Published: May 27, 2019
Abstract
Cocaine is known to increase the extracellular levels of dopamine (DA) and serotonin (5-HT) by inhibiting the neuronal reuptake of these monoamines. However, individuals with reduced monoamine reuptake transporter expression do not display a reduction in cocaine intake, suggesting that a mechanism other than inhibition of monoamine reuptake contributes to the rewarding and addictive effects of the psychostimulant. Here we report that cocaine...
Paper Details
Title
Action of cocaine involves depletion of dopaminergic and serotonergic storage vesicles
Published Date
May 27, 2019
Journal
Pages
651505
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