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Spectroscopic characterizations, structural peculiarities, molecular docking study and evaluation of biological potential of newly designed organotin(IV) carboxylates

Published on May 1, 2019in Journal of Photochemistry and Photobiology B-biology4.07
· DOI :10.1016/j.jphotobiol.2019.111516
Muhammad Sirajuddin13
Estimated H-index: 13
(University of Science and Technology),
Saqib Ali29
Estimated H-index: 29
(QAU: Quaid-i-Azam University)
+ 3 AuthorsAbdul Wadood19
Estimated H-index: 19
(AWKUM: Abdul Wali Khan University Mardan)
Abstract
Abstract In the search for new therapeutic agents we have synthesized 13 new organotin(IV) carboxylate derivatives of ( E )-4-((4-methoxy-2-nitrophenyl)amino)-4-oxobut-2-enoic acid. The synthesized complexes were characterized by several spectroscopic techniques. A chelating or bridging bidentate nature of the carboxylate ligand was suggested from the solid state FT-IR results. Solution state multinuclear NMR ( 1 H, 13 C and 119 Sn) results reveal that the geometry around the Sn atom in triorganotin(IV) complexes is trigonal bipyramidal and in diorganotin(IV) complexes is octahedral. The ligand, ( E )-4-((4-methoxy-2-nitrophenyl)amino)-4-oxobut-2-enoic acid, complex 1 and complex 2 were also analyzed by single crystal X-ray technique and the results fully supports the spectroscopic data. For 1 and 2 the geometry optimized by the single crystal X-ray analyses is distorted trigonal bipyramidal. The interaction of the studied compounds with SS-DNA was investigated by UV–Vis. Spectroscopy and Molecular docking showing an intercalative mode of binding. The evaluation of the screened compounds for cancer treatment displays even higher than that of the vincristine used as a standard drug. Similarly the performance of the tested compounds as an antileishmanial agent considers them very close in activity to the standard drug, amphotericin B. The antibacterial results show that the most of the compounds have a moderate sensitivity against the studied bacterial pathogens.
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References50
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#1Jai Devi (Guru Jambheshwar University of Science and Technology)H-Index: 5
#2Sushila Pachwania (Guru Jambheshwar University of Science and Technology)H-Index: 1
#1Akhtar Munir (QAU: Quaid-i-Azam University)H-Index: 3
#2Muhammad Sirajuddin (University of Science and Technology)H-Index: 13
Last.I. Aziz (QAU: Quaid-i-Azam University)H-Index: 1
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#1Farzana Shaheen (Allama Iqbal Open University)H-Index: 1
#2Muhammad Sirajuddin (University of Science and Technology)H-Index: 13
Last.Khadija Shahid (Riphah International University)H-Index: 3
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#1Wajid Rehman (HU: Hazara University)H-Index: 14
#2Rehana Yasmeen (Gomal University)H-Index: 2
Last.Khurshid Ayub (CUI: COMSATS Institute of Information Technology)H-Index: 22
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