Predicting Severe Infection and Effects of Hypogammaglobulinemia During Therapy With Rituximab in Rheumatic and Musculoskeletal Diseases

Yuzaiful Md Yusof; Edward M Vital; Damien McElvenny; Elizabeth M A Hensor; S. Das; Shouvik Dass; Andy C. Rawstron; Maya H Buch; Paul Emery; Sinisa Savic

doi:https://doi.org/10.1002/art.40937

doi.org/10.1002/art.40937

Predicting Severe Infection and Effects of Hypogammaglobulinemia During Therapy With Rituximab in Rheumatic and Musculoskeletal Diseases

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..., Sinisa Savic

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Volume: 71, Issue: 11, Pages: 1812 - 1823

Published: Sep 26, 2019

Abstract

Objective To evaluate predictors of serious infection events ( SIE s) during rituximab ( RTX ) therapy and effects of hypogammaglobulinemia on SIE rates, and humoral response and its persistence after discontinuation of RTX in the treatment of rheumatic and musculoskeletal diseases ( RMD s). Methods A retrospective longitudinal study of 700 RMD patients treated with RTX in a single center was conducted. Immunoglobulin levels were measured at...

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Paper Details

Title

Predicting Severe Infection and Effects of Hypogammaglobulinemia During Therapy With Rituximab in Rheumatic and Musculoskeletal Diseases

DOI

doi.org/10.1002/art.40937

Published Date

Sep 26, 2019

Volume

71

Issue

11

Pages

1812 - 1823

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