Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer

Volume: 21, Issue: 1
Published: May 14, 2019
Abstract
Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects in preclinical experiments and is currently undergoing clinical trials in several human malignancies, including triple-negative breast cancer (TNBC). However, response to glutaminase inhibitors is variable and...
Paper Details
Title
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer
Published Date
May 14, 2019
Volume
21
Issue
1
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