TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
Abstract
Low frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls. Similarly, TREM2 risk variant carriers also exhibit differential CSF TREM2 levels. TREM2 has three different alternative transcripts, but most of the functional studies only model the longest transcript. No studies have analyzed TREM2 expression levels or...
Paper Details
Title
TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
Published Date
May 8, 2019
Journal
Volume
14
Issue
1
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