The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study

Study Objectives To examine independent associations of sleeplessness and high-sensitivity C-reactive protein (hsCRP) with risk of chronic musculoskeletal pain, and to explore the joint effect of sleeplessness and hsCRP on risk of chronic musculoskeletal pain. Methods A population-based prospective study of 3214 women and 3142 men (mean age: 55.4, range: 32–87) without severe chronic musculoskeletal pain and with hsCRP ≤ 10 mg/L at baseline in...