Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly
Abstract
The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery. A broad range of translation initiation factors are also commonly found to be either amplified or mis-regulated in tumours, including eIF4E (elongation initiation factor 4E). eIF4E is a subunit of the eIF4F protein initiation complex and required for its recruitment....
Paper Details
Title
Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly
Published Date
May 22, 2019
Journal
Volume
17
Issue
1
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