Toward Axonal System Biology: Genome Wide Views of Local mRNA Translation

Neurons present a highly polarized morphology, often displaying a significantly imbalanced distribution of the cytoplasm between the somatic and axonal domains. This imbalance requires cell‐specific mechanisms for the maintenance of the axoplasmic mass during development, neuronal homeostasis, and recovery after injury. Although it has been clearly demonstrated that axoplasmic transport contributes a large amount of proteins to the axons, local...