175. Targeting the Gut-Brain Axis to Regulate Preference and Striatal Response to Fat

High fat diet (HFD) leads to disrupted striatal dopamine function and alterations in fat preference. One mechanism by which this occurs is depletion of gut lipid messengers, including oleoylethanolamine (OEA), which when replenished rescues dopamine response and increases preference for low fat emulsions via the generation of vagal afferent signals (Tellez et al., 2013). Using a supplement containing the OEA precurser...