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Purified protein derivative as intralesional immunotherapy for treatment of warts: Selection of the appropriate population is crucial.

Published on Oct 1, 2019in Journal of The American Academy of Dermatology7.102
· DOI :10.1016/j.jaad.2019.05.035
Roya S. Nazarian (ISMMS: Icahn School of Medicine at Mount Sinai), Beth N. McLellan4
Estimated H-index: 4
(Albert Einstein College of Medicine)
Abstract
  • References (4)
  • Citations (0)
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References4
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Background Without clear evidence, selecting among the existing immunotherapeutic options for warts remains challenging. Objective Through network meta-analyses, we aimed to evaluate the comparative efficacy of different intralesional immunotherapeutic modalities. Methods We included randomized controlled trials comparing intralesional immunotherapeutic modalities to cryotherapy, placebo, or imiquimod. All outcomes were presented as odds ratios (ORs) with 95% confidence intervals. Both conventio...
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Despite nearly a century of use, Bacille Calmette-Gue´rin (BCG) remains controversial, with known variations in BCG substrains, vaccine efficacy, policies, and practices across the world. Global information on BCG policies and practices may be useful for clinical interpretation of diagnostic tests as well as in the design of novel TB vaccines that are under development. URL:[http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001012].
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Bacille Calmette-Guerin (BCG) vaccination became compulsory in all governorates of Egypt in 1974. However a study of 1138 infants attending a private clinic or child welfare center in Cairo found that 624 (55%) had not been vaccinated. There was no significant difference in the vaccination rate between the 2 socioeconomic groups (56% at the private facility and 54% at the public clinic). 70% of the infants who showed evidence of vaccination and were tuberculin tested had negative results in the ...
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#1Sowmya Kaimal (St. John's Medical College)H-Index: 1
#2Hima Gopinath (AIIMS: All India Institute of Medical Sciences)
Last. Venkatesh Premalatha (St. John's Medical College)
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BACKGROUND: Cryotherapy and immunotherapeutic modalities elicit nonspecific immune response against the human papillomavirus. There is a paucity of literature on the effects of a sequential shift to immunotherapy in cryotherapy-resistant warts. AIM: To study the efficacy of intralesional purified protein derivative (PPD) immunotherapy in cryotherapy-resistant warts. METHODS: Patients with cryotherapy-recalcitrant cutaneous warts were given intralesional injections of PPD into the index warts (ol...
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