Purified protein derivative as intralesional immunotherapy for treatment of warts: Selection of the appropriate population is crucial.

Published on Oct 1, 2019in Journal of The American Academy of Dermatology7.102
· DOI :10.1016/j.jaad.2019.05.035
Roya S. Nazarian (ISMMS: Icahn School of Medicine at Mount Sinai), Beth N. McLellan4
Estimated H-index: 4
(Albert Einstein College of Medicine)
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Background Without clear evidence, selecting among the existing immunotherapeutic options for warts remains challenging. Objective Through network meta-analyses, we aimed to evaluate the comparative efficacy of different intralesional immunotherapeutic modalities. Methods We included randomized controlled trials comparing intralesional immunotherapeutic modalities to cryotherapy, placebo, or imiquimod. All outcomes were presented as odds ratios (ORs) with 95% confidence intervals. Both conventio...
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BACKGROUND: Cryotherapy and immunotherapeutic modalities elicit nonspecific immune response against the human papillomavirus. There is a paucity of literature on the effects of a sequential shift to immunotherapy in cryotherapy-resistant warts. AIM: To study the efficacy of intralesional purified protein derivative (PPD) immunotherapy in cryotherapy-resistant warts. METHODS: Patients with cryotherapy-recalcitrant cutaneous warts were given intralesional injections of PPD into the index warts (ol...