Branched-chain polyamine stabilizes RNA polymerase at elevated temperatures in hyperthermophiles
Abstract
Branched-chain polyamines (BCPAs) are unique polycations found in (hyper)thermophiles. Thermococcus kodakarensis grows optimally at 85 °C and produces the BCPA N4-bis(aminopropyl)spermidine by sequential addition of decarboxylated S-adenosylmethionine (dcSAM) aminopropyl groups to spermidine (SPD) by BCPA synthase A (BpsA). The T. kodakarensis bpsA deletion mutant (DBP1) did not grow at temperatures at or above 93 °C, and grew at 90 °C only...
Paper Details
Title
Branched-chain polyamine stabilizes RNA polymerase at elevated temperatures in hyperthermophiles
Published Date
May 17, 2019
Journal
Volume
52
Issue
2
Pages
275 - 285
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