Original paper
HIC 2, a new transcription activator of SIRT 1
Abstract
The protein deacetylase SIRT1 is crucial to numerous physiological processes, such as aging, metabolism, and autoimmunity, and is repressed by various transcription factors, including HIC1. Conversely, we found that HIC2, which is highly homologous to HIC1, is a transcriptional activator of SIRT1 due to opposite activity of the intermediate domains of the two homologs. Importantly, this relationship between HIC2 and SIRT1 could be important for...
Paper Details
Title
Published Date
Jun 4, 2019
Journal
Volume
593
Issue
14
Pages
1763 - 1776
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Notes
History