Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy
Abstract
•Analysis of conformational dynamics throughout the M2R using 13CH3-ε-methionine NMR•Ligands with various efficacies for G protein and arrestin signaling were examined•Each ligand stabilized a distinct conformation of the M2R•There is no clear linear correlation between ligand efficacy and chemical shifts The M2 muscarinic acetylcholine receptor (M2R) is a prototypical GPCR that plays important roles in regulating heart rate and CNS functions....
Paper Details
Title
Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy
Published Date
Jul 1, 2019
Journal
Volume
75
Issue
1
Pages
53 - 65.e7
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