Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrils

Abstract
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid plaques surrounded by microglia. In cell culture, microglia internalize fibrillar β-amyloid but do not degrade it efficiently. Unactivated microglia have a relatively high lysosomal pH, which impairs the activity of lysosomal proteases. Previous studies showed that activation of microglia with macrophage colony stimulating factor decreases lysosomal pH and enhances...
Paper Details
Title
Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrils
DOI
Published Date
May 16, 2019
Journal
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