Directional stimulation of subthalamic nucleus sweet spot predicts clinical efficacy: Proof of concept

Background Directional deep brain stimulation (dDBS) of the subthalamic nucleus for Parkinson's disease (PD) increases the therapeutic window. However, empirical programming of the neurostimulator becomes more complex given the increasing number of stimulation parameters. A better understanding of dDBS is needed to improve therapy and help guide postoperative programming. Objective To determine whether clinical effects of dDBS can be predicted...