Multicentre study of perioperativeversusadjuvant chemotherapy for resectable colorectal liver metastases

It is not known whether perioperative chemotherapy, compared with adjuvant chemotherapy alone, improves disease-free survival (DFS) in patients with upfront resectable colorectal liver metastases (CLM). The aim of this study was to estimate the impact of neoadjuvant 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX) on DFS in patients with upfront resectable CLM.Consecutive patients who presented with up to five resectable CLM at two Japanese...