118. The Challenges of Testing D1 Agonists in Schizophrenia

Multiple lines of research have converged to suggest a prominent role for the D1 receptor in the treatment of cognitive deficits in schizophrenia. D1 is a prominent mediator of dopamine’s effects in the prefrontal cortex, and there is robust evidence for suboptimal stimulation of D1 receptors in dorso-lateral prefrontal cortex in schizophrenia, suggesting that D1 agonists may be...