F126. Nucleus Accumbens Volume Predicts Allostatic Load and is Moderated by Sex and Treatment Modality in Youth With Depression and Obesity

Youth with depressive disorders and obesity share reward circuit anatomical and functional abnormalities. These disorders can be conceptualized under an allostatic load (AL) model, or cumulative wear and tear on the body. Modification of AL may help improve overall health outcomes. While studies have examined the role of sex and treatment type on depression outcomes, none have evaluated relations between structure in this reward circuit and AL,...