Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by the deposition of extracellular fibrillar amyloid β (fΑβ) and the intracellular accumulation of neurofibrillary tangles. As AD progresses, Aβ drives a robust and prolonged inflammatory response via its recognition by microglia, the brain's immune cells. Microglial reactivity to fAβ plaques may impair their normal surveillance duties, facilitating synaptic...
Paper Details
Title
Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
Published Date
Apr 16, 2019
Journal
Volume
16
Issue
1
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