Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis

Volume: 129, Issue: 8, Pages: 3277 - 3292
Published: Jul 15, 2019
Abstract
The migration of leukocytes into the CNS drives the neuropathology of multiple sclerosis (MS). It is likely that this penetration utilizes energy resources that remain to be defined. Using the experimental autoimmune encephalomyelitis (EAE) model of MS, we determined that macrophages within the perivascular cuff of postcapillary venules are highly glycolytic, as manifested by strong expression of lactate dehydrogenase A (LDHA), which converts...
Paper Details
Title
Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis
Published Date
Jul 15, 2019
Volume
129
Issue
8
Pages
3277 - 3292
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