Brain cytochrome‐c‐oxidase as a marker of mitochondrial function: A pilot study in major depression using NIRS
Abstract
Background Brain mitochondrial dysfunction is implicated in the pathophysiology of mood disorders. Brain cytochrome-c-oxidase (COX) activity is associated with the mitochondrial function. Near-infrared spectroscopy (NIRS) noninvasively measures oxidized COX (oxCOX) and tissue oxygenation index (TOI) reflecting cerebral blood flow and oxygenation. Methods oxCOX and TOI were assessed in prefrontal cortex (Fp1/2, Brodmann area 10) in patients in a...
Paper Details
Title
Brain cytochrome‐c‐oxidase as a marker of mitochondrial function: A pilot study in major depression using NIRS
Published Date
May 21, 2019
Journal
Volume
36
Issue
8
Pages
766 - 779
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