A novel inhibitor of complement C5 provides structural insights into activation

Pages: 647354
Published: May 23, 2019
Abstract
null The complement system is a crucial part of innate immune defences against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation. We have identified a novel class of inhibitors from tick saliva, the CirpT family, and generated detailed structural data revealing their mechanism of action. We show direct binding of a CirpT to...
Paper Details
Title
A novel inhibitor of complement C5 provides structural insights into activation
Published Date
May 23, 2019
Journal
Pages
647354
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