The RNA binding protein HuR influences skeletal muscle metabolic flexibility in rodents and humans

Background Metabolic flexibility can be assessed by changes in respiratory exchange ratio (RER) following feeding. Though metabolic flexibility (difference in RER between fasted and fed state) is often impaired in individuals with obesity or type 2 diabetes, the cellular processes contributing to this impairment are unclear. Materials and methods From several clinical studies we identified the 16 most and 14 least metabolically flexible male and...