Hydrolyzable Tannins Are Iron Chelators That Inhibit DNA Repair Enzyme ALKBH2

Volume: 32, Issue: 6, Pages: 1082 - 1086
Published: May 15, 2019
Abstract
Hydrolyzable tannins are a class of polyphenolic compounds commonly found in natural products. In this work, we studied the in vitro inhibitory mechanism of six molecules in this class on ALKBH2, an Fe(II)/α-ketoglutarate-dependent DNA repair enzyme in the AlkB family. We determined the IC50 values of these compounds on the repair of 3-methylcytosine and 1-methyladenine, the prototypical substrates of ALKBH2. A structure–activity relationship...
Paper Details
Title
Hydrolyzable Tannins Are Iron Chelators That Inhibit DNA Repair Enzyme ALKBH2
Published Date
May 15, 2019
Volume
32
Issue
6
Pages
1082 - 1086
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